How Does Long-Term Obesity Affect the Immune System and Bone?
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چکیده
Introduction: Obesity, a serious condition leading to diseases such as Type II diabetes (T2D), is known to impair immune response, yet their impacts on the bone marrow niche and bone quality are still unclear. In this study, a murine model of diet-induced obesity (DIO) was used to investigate the relationship between an increasing adipose burden on phenotypic and dysfunctional changes in bone marrow immune cells (B and T cells), bone quality and the overall health (e.g., glucose tolerance) of the animal. Additionally, DIO-related changes in circulating immune cells and soluble factors such as tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), and macrophage inflammatory protein-1-beta (MIP-1β) were evaluated.
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